Arterial hypertension is a leading risk factor for the development of stroke. It significantly reduces the quality of life of the individual and the community, and can end in a premature fatal outcome. Treatment of arterial hypertension is lifelong, and the causes of non-adherence to antihypertensive therapy are multiple. The objectives of the study were to determine the persistence of patients in taking antihypertensive drugs, and whether there are differences in relation to the level of education, age and gender. The study was conducted using the MMAS-8 questionnaire to assess drug persistence. 74 patients hospitalized in the Cerebrovascular Diseases Unit of the Department of Neurology of the General Hospital Pula participated in the period from 22.10.2020. to 27.01.2021. All of them had a previous diagnosis of arterial hypertension, had prescribed antihypertensive drugs in therapy and were admitted to hospital for the development of a stroke. IBM SPSS Statistics 27 statistical program was used in data processing. Descriptive statistical analysis, Kolmogorov-Smirnov test for testing normality of distribution, methods of nonparametric statistics and Mann Whitney-U test for testing hypotheses were used. According to the data obtained by the MMAS-8 questionnaire, patients can be grouped into three categories according to their cooperation in taking antihypertensive drugs; 35.1% or 26 patients were cooperative, 44.6% or 33 patients were poorly cooperative, and 20.3% or 15 patients were uncooperative. No statistically significant differences in the persistence of therapy in relation to education level, ageand gender were found. Although one third of the respondents in this research are cooperative, it is necessary to examine the reasons for non-cooperation and lower cooperation in the remaining two thirds of the respondents. It is also necessary for nurses and technicians to conduct continuous education, monitoring and support for hypertensive patients.