Sustainable tourism can be defined as „tourism that fully takes into account the current and future economic, social and environmental effects, taking care of the needs of visitors, sector, environmental and destinations“. The guidelines and management practices of sustainable development of tourism can be applied to all forms of tourism, and in all kinds of destinations. In this case, if cultural tourism wants to be sustainable it has to deal with some challenges that may get in the way. These challenges include cooperation between cultural and tourism sector, the management of cultural heritage, the benefits that will generate the local community on the development of sustainable cultural tourism, the impact of lifelong learning for sustainable development of destinations and responsible marketing to introduce tourists with the cultural heritage and behavior in the destination. It is essential to achieve effective cooperation between the two sectors and to set up training and education programs to the local population as well as the tourism management and culture heritage management and improve the quality of life in the area.