Multiple sclerosis is an autoimmune inflammatory chronic demyelinating disease of the central nervous system. The disease is relapsing in nature and occurs mostly in young individuals and progresses throughout life with later stages characterized with neurodegeneration and irreversible impairment. The diagnosis of the disease is based on the recognition of characteristic clinical symptoms and is confirmed by paraclinical procedures. Clinical symptoms most commonly begin with clinically isolated syndrome, a combination of optic neuritis, internuclear ophthalmoplegia, and partial transverse myelitis. Later symptoms affect almost every organ system with marked impairment of visual, motor and sensory functions, as well as impaired coordination and balance and progressive cognitive decline. Of the paraclinical procedures used in the diagnosis of multiple sclerosis, the most important is magnetic resonance imaging of the brain and spinal cord, analysis of visual evoked potentials and analysis of cerebrospinal fluid are also used. Due to the inability to treat the cause of the disease, the goals of treatment are to overcome acute seizures and reduce the time required to recover after an attack, reduce the number of seizures and try to slow down the course of disease development. For these purposes, corticosteroids are used in acute seizures, various drugs that affect the symptoms of the disease and drugs that change the course of the disease as a promising new therapy that reduces the number and severity of relapses. This paper highlights the role of the nurse as a key member of the medical team caring for a patient with multiple sclerosis as well as the importance of a holistic approach due to the nature of the disease which not only affects many biological functions but also brings many psychological problems that affect the patients as well as their loved ones. The role of the nurse was analyzed through all stages of the disease, from participation in diagnosing, treatment and treating the symptoms to educating patients and their families about the disease and providing advice and support when needed.