Health tourism requires specific natural resources, among which thermal springs are key. In Croatia, especially in the region of Central Croatia, there is a wealth of thermal springs that have historically been used for medical treatment and wellness, for example in the Varaždin, Daruvar, Krapina and Topusko spas. Thermal springs provide the basis for the development of health, wellness and medical tourism, which contributes to the economic development of local communities. Central Croatia is crucial for the development of health and wellness tourism thanks to the wealth of thermal springs. However, achieving success requires a national strategy, adequate management of resources and regulation of tourism and health services. Also, branding and differentiation are important for positioning Croatia as a health tourism destination on a global level. Correct valorization of thermal resources can bring economic progress, ecological sustainability and strengthening of Croatia's competitiveness in this sector. The aim of this work is to analyze the current situation and trends in the use of thermal waters for health tourism in Croatia, with a focus on selected thermal destinations.