The process of regional integration begins when countries decide to merge their markets to remove customs and non-tariff barriers that allow them to move goods, services, people and capital freely. The motives for integration maybe different, economic or political. The degree of integration depends on how much the countries want to integrate and remove borders. The key question is also whether the outcome is positive or negative. Regional integration in South America were needed in the post-war period,for countries to recover and to move on. The integrations discussed in this paper are LAFTA, the ANDEAN Community, and MERCOSUR.The integration of LAFTA integration failed because the Member States were differently developed. Although a contract was designed to harmonize this development, it was not successfully implemented.The ANDEAN Community was established with the aim of promoting the exchange of goods and services between Member States, but it took them more than 35 years to successfully implement the Free Trade Area. This integration is constantly making efforts to improve relationships with other integrations. The economic situation in the Member States is not very good, and it has become a necessity to work on the infrastructure because that is the key to the change.MERCOSUR as the most important regional integration of the South American teritory, faces the problem of low intra-regional trade, but very well developed outside regional trade. Like other countries in South America, there is a problem of poverty and unequal development among Member States, but thanks to further development of technology, it can be expected that these countries will soon increase their development. MERCOSUR continues to continuoues maintain and build relationships with integrations across the continent.