Palliative medicine, a relatively new branch of medicine, deals with the treatment and suppression of symptoms of malignant and advanced diseases, improving the quality of life of patients and controlling pain. The results of palliative medicine can be measured by the absence of pain and the satisfaction of the patient and his family. Although palliative medicine is primarily a part of the medical domain, the participation of the nurse and the multidisciplinary team in acting with a holistic approach within palliative care is inevitable. The beginnings of hospice and palliative care in Croatia go back to the distant past, when the first xenodochium, an institution for the care of the infirm, was opened in Zadar. The palliative multidisciplinary team consists of a whole range of specialists; doctor, nurse, psychologist, pharmacist, physiotherapist, anesthesiologist, clergyman, priest, social worker. Pain, as a protective mechanism of the body, is ubiquitous in palliative patients, and thus one of the main tasks of the nurse is to recognize it and reduce it or eliminate it completely. We classify pain according to the speed of onset, cause, intensity, pathophysiological changes, quality and duration. Also, physiological and psychological influences determine the final experience of pain and the threshold of tolerance. The nurse detects pain in patients by observing behavior and with the help of unidimensional and multidimensional scales. For palliative patients, chronic pain relief methods must be preventive, continuous and applied already at low intensity. These methods can be classified into pharmacological, non-pharmacological and invasive anesthetic treatment. Nursing assessment of pain involves assessing the stage of pain, the patient's behavior and recognizing the impact of pain on the patient. It is necessary to determine the factors that influence the occurrence of pain and the patient's response to them. Major defining characteristic of pain is the patient's statement about the existence of pain, and the nurse must act on it. Nursing interventions must be aimed at alleviating and controlling pain. Data collection, planning and implementation of a health care plan, application and maintenance of pharmacotherapy, providing emotional and psychological support to the patient and his family, communication, anxiety reduction, cutaneous stimulation, massage, cryotherapy and thermotherapy, music therapy, pet therapy, distraction from pain, eliminating the feeling of loneliness, guided visualization and meditation, individualized education of the patient and family and other individualized non-pharmacological methods of pain control within nursing competence are some of the most important nursing techniques for pain control. After the implemented interventions to reduce and suppress pain, the nurse evaluates the effectiveness of the interventions in order to assess their quality and possible changes or continuation of the same methods. The expected outcomes are reduced pain intensity and the patient's increased degree of tolerance and positive confrontation with pain for the purpose of a better quality of life and performing daily life activities without feeling powerless and constantly hindered. It is important to emphasize that the nurse must act within her competences.