The performance of clinical nurses is influenced by many factors, which are divided into three according to their perspectives: individual (work stress), situation (load) and regulations (supervision). The aim of this final paper is to determine the levels of exhaustion, alienation, work control and the psychological demands of nurses' work, and to compare these measures of workload, considering whether nurses work in a hospital ward or an outpatient clinic, and considering how well they assess the organization of work in the institution and at their workplace. The sample included 109 nurses of both sexes who are employees of the Pula General Hospital. The following groups were included in the research: nurses who work in the hospital polyclinic and nurses who work in the hospital ward. The following questionnaires were used: General Data Questionnaire, Oldenburg Burnout Questionnaire, Psychological Demands and Job Control Questionnaire, and Work Organization Assessment Questionnaire. The results show that nurses expereince burnout at all workplaces. Both exhaustion and alienation are greater in nurses who assess the work organization as poor, either in the institution or at the workplace. Nurses in the outpatient clinic express higher exhaustion that nurses int he ward. Nurses estimate that there are more psychological work demands in the ward than in the outpatient clinic, and they have more control over their work in the outpatient clinic especially when the work organization is better.