Health tourism is one of the specific selective forms of tourism. Throughout history, people have very early on become aware of taking care of their health and actively seeked ways in which it can have a beneficial effect on the organism. Health tourism is a complex touristic product which includes wellness, health care and medical tourism. The resource base for health tourism are natural healing factors such as the sea, algae, sun, thermomineral waters, naftalan, with the purpose of maintaining and improving one's health. Trends which contribute to the population ageing include a poor relationship to lifestyle, COVID-19, insufficient engagement in activities and the like. Wellness centers and spas are mostly privately owned, whereas treatment centers, special hospital and hospice care systems are a part of the public health sector. Thalassotherapia Opatija is analyzed as a case study, which is a Special Hospital for Medical Rehabilitation for diseases concerning rheumatism, lungs and heart. Thalassotherapia has had a number of positive changes, and it achieves excellence as a rheumatology center, in physical medicine, sports medicine and medical wellness. Croatia has a tremendously favorable potential for health tourism development, particularly medical and wellness tourism. Contributions to the development of health tourism primarily allow filling out of its capacity, as well as, the complement of the tourism supply.