Manic-depression or bipolar affective disorder belongs to a group of mood disorders. It is characterized by a change in depressive and manic phases, which greatly affects the daily life of the patient and the behavior, mood and perception of the environment in which he lives. The cause of the manic-depressive disorder is unknown, but genetic and psychosocial factors are considered to play a significant role. According to the official classification MKB-10, which has been in use in Croatia since 1995, the manic-depressive disorder is classified as mood disorder and is classified under the category F30 to F31 .9. According to The DMS classification (American Psychiatric Association 2014), manic depressive disorder is classified as Bipolar Type 1 disorder, Bipolar Type 2 disorder, Cyclotic disorder and Bipolar disorder – indeterminate Treatment of manic-depressive disorder is pharmacological and psychotherapeutic. Psychopharmacological treatment methods are used: antidepressants, mood stabilisers, antipsychotics and antiepileptics. Psychotherapeutic approach: cognitive-behavioral therapy, family therapy, interpersonal therapy and psychotherapy. Treatment is performed in an ambulance in the daily hospital and psychotherapeutic groups and in psychiatric departments, depending on the patient's condition. The nurse at the Department of Psychiatry acts as part of a multidisciplinary team consisting of psychiatrist, nurse, working therapist, social worker, psychologist and others. In her work she applies all principles of psychiatric health care. By applying them, she actively includes the patient in therapy and rehabilitation in hospital and outpatient conditions. The main tool in the work of the nurse in the psychiatric ward is quality education, which includes knowledge about psychiatric diseases, basic knowledge about pharmacotherapy and socio-therapeutic and psychotherapeutic methods of treatment. Only a well-educated psychiatric nurse can work well on the destigatisation and discrimination of psychiatric patients.