This paper focuses on life and work in Dubrovnik during the period of mercantilism, a period that lasted from the 15th to 18th centuries. Mercantilism on the basis of state wealth is considered to be a stock of gold, so state measures stimulate monopolistic possession of raw materials, imposing taxes, encouraging their own exports, investments in trade and commerce and encouraging the conquest of new markets. Mercantilism was abandoned in the 19th century for the benefit of free games, and as a consequence of the emergence of mercantilism, trade union, community of finance, communality of state administration and colonial policy were created. The development of mercantilism was affected by the technical progress that was especially used in the works of crafts, trade and maritime affairs. Mercantilism was most developed in Croatia in the area of the Republic of Dubrovnik, which had developed commerce and activities of knitting and needles. In the 17th century, there was an economic downturn because the state had large expenditures on the Ottoman Empire, weakened trade, and the economic downturn affected by the earthquake that occurred in 1667. The Revolt of the Senate on the Recovery of the City was handed over by diplomat Stjepan Gradić in the form of a file. The greatest attention was focused on the opening of new trades and manufactures, the restoration of textile production, and the tanning of leather, thus preventing imports. Art was a significant period of Gothic in which Juraj Dalmatinac and Nikola Božidarević acted.